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| Title: | | SOLUTION STRUCTURE OF A DNA DUPLEX CONTAINING M1G OPPOSITE A 2 BASE PAIR DELETION | |
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| Molecular Description: | 5'-D(ApTpCpGpCp(M1G)pCpGpGpCpApTpG)-3' |
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| Nucleic Acid Sequence: |
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| Chain | A: | | (DA) (DT) (DC) (DG) (DC) (M1G) (DC) (DG) (DG) (DC) (DA) (DT) (DG) |
| Chain | B: | | (DC) (DA) (DT) (DG) (DC) (DC) (DG) (DC) (DG) (DA) (DT) |
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| Primary Citation: | Schnetz-Boutaud, N.C., Saleh, S., Marnett, L.J., Stone, M.P.
The exocyclic 1,N2-deoxyguanosine pyrimidopurinone M1G is a chemically stable DNA adduct when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene.
Biochemistry
, 40,
pp. 15638 - 15649, 2001.
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Experimental Information: | SOLUTION NMR |
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Number of Models: | 1 Model |
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| Sample Details: |
2mM DNA, 10mM phosphate buffer, 0.1M NaCl, 50 uM EDTA , pH 7
99.96% D2o
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