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| Title: | | SOLUTION STRUCTURE OF THE 8,9-DIHYDRO-8-(N7-GUANYL)-9-HYDROXY-AFLATOXIN B1 ADDUCT MISPAIRED WITH DEOXYADENOSINE | |
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| Molecular Description: | 5'-D(ApCpApTpCp(X)pApTpCpT)-3' |
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| Nucleic Acid Sequence: |
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| Chain | A: | | (DA) (DC) (DA) (DT) (DC) X (DA) (DT) (DC) (DT) |
| Chain | B: | | (DA) (DG) (DA) (DT) (DA) (DG) (DA) (DT) (DG) (DT) |
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| Primary Citation: | Giri, I., Johnston, D.S., Stone, M.P.
MISPAIRING OF THE 8,9-DIHYDRO-8-(N7-GUANYL)-9-HYDROXY-AFLATOXIN B1 ADDUCT WITH DEOXYADENOSINE RESULTS IN EXTRUSION OF THE MISMATCHED DA TOWARD THE MAJOR GROOVE
Biochemistry
, 41,
pp. 5462 - 5472, 2002.
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Experimental Information: | SOLUTION NMR |
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Number of Models: | 1 Model |
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| Sample Details: |
80 OD of d(ACATCAFBGATCT)d(AGATAGATGT) solution in NMR Buffer
For observation of nonexchangeable protons, the sample was dissolved in 0.5 mL of 0.01 M sodium phosphate containing 0.1 M NaCl and 0.05 mM Na2EDTA at pD 7.4. The sample was dissolved in 99.96% D2O. For observation of exchangeable protons, the sample was dissolved in 9:1 H2O:D2O. Most experiments were performed at 5 C. Spectra of exchangeable protons were obtained at 0 C.
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