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| Title: |  | NMR STRUCTURE OF THE PARALLEL-STRANDED DNA QUADRUPLEX D(TTAGGGT)4 COMPLEXED WITH THE TELOMERASE INHIBITOR RHPS4 |  |
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| Molecular Description: | 5'-D(TpTpApGpGpGpT)-3'
3,11-DIFLUORO-6,8,13-TRIMETHYL-8H-QUINO[4,3,2-KL]ACRIDIN-13-IUM |
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| Nucleic Acid Sequence: |
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| Chains | A, B, C, D: | |
(DT) (DT) (DA) (DG) (DG) (DG) (DT)
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| Primary Citation: | Gavathiotis, E., Heald, R.A., Stevens, M.F.G., Searle, M.S.
Drug Recognition and Stabilisation of the Parallel-stranded DNA Quadruplex d(TTAGGGT)4 Containing the Human Telomeric Repeat
J.Mol.Biol.
, 334,
pp. 25 - 36, 2003.
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Experimental Information: | NMR |
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Number of Models: | 10 STRUCTURES |
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| Sample Details: |
1.6mM 2:1 RHPS4-d(TTAGGGT)4, 100 mM KCl, 10 mM K2HPO4 buffer, 1 mM EDTA,90% H2O, 10% D2O
90% H2O, 10% D2O
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