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| Title: | | CRYSTAL STRUCTURE ANALYSIS OF A 2'-O-[2-(METHYLTHIO)-ETHYL]-MODIFIED OLIGODEOXYNUCLEOTIDE DUPLEX | |
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| Molecular Description: | 5'-D(GpCpGpTpApSMTpApCpGpC)-3' |
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| Structural Features: | A DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chains | A,B: | | (DG) (DC) (DG) (DT) (DA) (SMT) (DA) (DC) (DG) (DC) |
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| Primary Citation: | Prakash, T.P., Manoharan, M., Kawasaki, A.M., Fraser, A.S., Lesnik, E.A., Sioufi, N., Leeds, J.M., Teplova, M., Egli, M.
2'-O-[2-(Methylthio)ethyl]-Modified Oligonucleotide: An Analogue of 2'-O-[2-(Methoxy)-ethyl]-Modified Oligonucleotide with Improved Protein Binding Properties and High Binding Affinity to Target RNA
Biochemistry
, 41,
pp. 11642 - 11648, 2002.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
21
21
21
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| Cell Constants: |
| a = 24.728 | b = 44.473 | c = 46.229 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the SHELXL-97 program.
The R value is
13.7
for 12784 reflections
in the resolution range 15.0 to
1.25 Ångstroms
with I > 2.0 sigma(I).
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