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| Title: | | CRYSTAL STRUCTURE OF THE A-DNA GCGTAT*CGC WITH A 2'-O-[2-(N,N-DIMETHYLAMINOOXY)ETHYL] THYMIDINE (T*) | |
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| Molecular Description: | 5'-D(GpCpGpTpAp(2OT)pApCpGpC)-3' |
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| Structural Features: | A DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chains | A,B: | | (DG) (DC) (DG) (DT) (DA) (2OT) (DA) (DC) (DG) (DC) |
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| Primary Citation: | Egli, M., Minasov, G., Tereshko, V., Pallan, P.S., Teplova, M., Inamati, G.B., Lesnik, E.A., Owens, S.R., Ross, B.S., Prakash, T.P., Manoharan, M.
Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2'-O-Ribonucleic Acid Modifications.
Biochemistry
, 44,
pp. 9045 - 9057, 2005.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
21
21
21
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| Cell Constants: |
| a = 24.840 | b = 44.640 | c = 45.180 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the CNS program.
The R value is
16.3
for 6099 reflections
in the resolution range 20.0 to
1.65 Ångstroms
with Fobs > 0.0 sigma(Fobs).
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