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| Title: | | MULTIPLE BINDING MODES OF ANTICANCER DRUG ACTINOMYCIN D: X-RAY, MOLECULAR MODELING, AND SPECTROSCOPIC STUDIES OF D(GAAGCTTC)2-ACTINOMYCIN D COMPLEXES AND ITS HOST DNA | |
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| Molecular Description: | 5'-D(GpApApGpCpTpTpC)-3' |
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| Structural Features: | A DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chains | A, B, C, D: | |
(DG) (DA) (DA) (DG) (DC) (DT) (DT) (DC)
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| Primary Citation: | Kamitori, S., Takusagawa, F.
Multiple Binding Modes of Anticancer Drug Actinomycin D: X-Ray, Molecular Modeling, and Spectroscopic Studies of d(GAAGCTTC)2-Actinomycin D Complexes and Its Host DNA
J.Am.Chem.Soc.
, 116,
pp. 4154 - 4165, 1994.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
H
3
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| Cell Constants: |
| a = 70.540 | b = 70.540 | c = 53.300 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 120.00 | (degrees) |
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| Crystallization Conditions: |
| Method: | | VAPOR DIFFUSION |
| Drop: | | WATER, MPD, MgCl2, Na Cacodylate, Spermine HCl |
| Reservoir: | | WATER, MPD |
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| Refinement: | The structure was refined using the X-PLOR program.
The R value is
21.2
for 1035 reflections
in the resolution range 10.000 to
3.000 Ångstroms
with Fobs > 1.500 sigma(Fobs).
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