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| Title: | | CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA | |
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| Molecular Description: | 5'-R((C43)p(G48)p(C43)p(G48)p(A44)p
(A44)p(U36)p(U36)p(C43)p(G48)p(C43)p
(G48))-3' |
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| Structural Features: | A DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chains | A, B: | |
(C43) (G48) (C43) (G48) (A44) (A44) (U36) (U36) (C43) (G48) (C43) (G48)
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| Primary Citation: | Teplova, M., Minasov, G., Tereshko, V., Inamati, G.B., Cook, P.D., Manoharan, M., Egli, M.
Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA.
Nat.Struct.Biol.
, 6,
pp. 535 - 539, 1999.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
C
1
2
1
|
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| Cell Constants: |
| a = 44.06 | b = 35.400 | c = 48.340 | (Ångstroms) |
 = 90.00 |  = 95.00 |  = 90.00 | (degrees) |
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| Crystallization Conditions: |
| Drop: | | MgCl2, NA HEPES, PEG
400 |
| Reservoir: | | MgCl2, NA HEPES, PEG
400 |
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| Refinement: | The structure was refined using the X-PLOR 3.851 program.
The R value is
19.3
for 1881 reflections
in the resolution range 8.0 to
2.70 Ångstroms
with Fobs > 2.0 sigma(Fobs).
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