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| Title: | | 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'/ BENZIMIDAZOLE DERIVATIVE COMPLEX | |
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| Molecular Description: | 5'-D(CpGpCpGpApApTpTpCpGpCpG)-3'
BENZIMIDAZOLE DERIVATIVE |
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| Structural Features: | B DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chains | A, B: | |
(DC) (DG) (DC) (DG) (DA) (DA) (DT) (DT) (DC) (DG) (DC) (DG)
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| Primary Citation: | Squire, C.J., Baker, L.J., Clark, G.R., Martin, R.F., White, J.
Structures of m-iodo Hoechst-DNA complexes in crystals with reduced solvent content: implications for minor groove binder drug design.
Nucleic Acids Res.
, 28,
pp. 1252 - 1258, 2000.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
21
21
21
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| Cell Constants: |
| a = 24.913 | b = 34.153 | c = 61.296 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Crystallization Conditions: |
| Method: | | VAPOR DIFFUSION, HANGING DROP |
| Drop: | | MgCl2, SPERMINE, MPD, METHANOL, SODIUM CACODYLATE |
| Reservoir: | | MPD |
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| Refinement: | The structure was refined using the SHELXL-97 program.
The R value is
15.8
for 9194 reflections
in the resolution range 8.0 to
1.6 Ångstroms
with Fobs > 4.0 sigma(Fobs).
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