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| Title: | | ACRIDINE BINDING TO DNA | |
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| Molecular Description: | 5'-D(CpGpTpApCpG)-3' |
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| Structural Features: | RH DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chain | A: | | (DC) (DG) (DT) (DA) (DC) (DG) |
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| Primary Citation: | Todd, A.K., Adams, A., Thorpe, J.H., Denny, W.A., Wakelin, L.P.G., Cardin, C.J.
Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethlyamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5Br-U)ACG)2 at 1.3-angstrom resolution
J.Med.Chem.
, 42,
pp. 536 - 540, 1999.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
64
|
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| Cell Constants: |
| a = 30.161 | b = 30.161 | c = 39.692 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 120.00 | (degrees) |
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| Refinement: | The structure was refined using the SHELXL-97 program.
The R value is
20.2
for reflections
in the resolution range 16.0 to
1.6 Ångstroms
. |
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