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| Title: | | RELEASE OF THE CYANO MOIETY IN THE CRYSTAL STRUCTURE OF N-CYANOMETHYL-N-(2-METHOXYETHYL)-DAUNOMYCIN COMPLEXED WITH D(CGATCG) | |
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| Molecular Description: | 5'-D(CpGpApTpCpG)-3'
DAUNOMYCIN DERIVATIVE |
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| Structural Features: | RH DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chain | A: | |
(DC) (DG) (DA) (DT) (DC) (DG)
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| Primary Citation: | Saminadin, P., Dautant, A., Mondon, M., Langlois D'estaintot, B., Courseille, C., Precigoux, G.
Release of the cyano moiety in the crystal structure of N-cyanomethyl-N-(2-methoxyethyl)-daunomycin complexed with d(CGATCG).
Eur.J.Biochem.
, 267,
pp. 457 - 464, 2000.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
41
21
2
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| Cell Constants: |
| a = 28.160 | b = 28.160 | c = 53.400 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Crystallization Conditions: |
| Method: | | VAPOR DIFFUSION, HANGING DROP |
| Drop: | | MPD, LiCl, MgCl2, SODIUM CACODYLATE, [CO(NH3)6]CL3 |
| Reservoir: | | MPD |
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| Refinement: | The structure was refined using the X-PLOR program.
The R value is
23
for 3220 reflections
in the resolution range 12.60 to
1.54 Ångstroms
with Fobs > 2.0 sigma(Fobs).
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