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| Title: | | CRYSTAL STRUCTURE OF 5-F-9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE BOUND TO D(CGTACG)2 | |
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| Molecular Description: | 5'-D(CpGpTpApCpG)-3'
ACRIDINE DERIVATIVE |
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| Structural Features: | RH DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chain | A: | | (DC) (DG) (DT) (DA) (DC) (DG) |
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| Primary Citation: | Adams, A., Guss, J.M., Collyer, C.A., Denny, W.A., Prakash, A.S., Wakelin, L.P.
Acridinecarboxamide topoisomerase poisons: structural and kinetic studies of the DNA complexes of 5-substituted 9-amino-(N-(2-dimethylamino)ethyl)acridine-4-carboxamides.
Mol.Pharmacol.
, 58,
pp. 649 - 658, 2000.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
64
|
|
| Cell Constants: |
| a = 30.140 | b = 30.140 | c = 39.400 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 120.00 | (degrees) |
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| Refinement: | The structure was refined using the SHELXL-97 program.
The R value is
21.4
for 2978 reflections
in the resolution range 16.0 to
1.55 Ångstroms
with I > 0.0 sigma(I).
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