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| Title: | | CRYSTAL STRUCTURE OF THE COMPLEX OF CRYPTOLEPINE-D(CCTAGG)2 | |
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| Molecular Description: | 5'-D(CpCpTpApGpG)-3'
CRYPTOLEPINE |
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| Structural Features: | B DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chain | A: | | (DC) (DC) (DT) (DA) (DG) (DG) |
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| Primary Citation: | Lisgarten, J.N., Coll, M., Portugal, J., Wright, C.W., Aymami, J.
The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites.
Nat.Struct.Biol.
, 9,
pp. 57 - 60, 2002.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
64
|
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| Cell Constants: |
| a = 29.960 | b = 29.960 | c = 39.650 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 120.00 | (degrees) |
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| Refinement: | The structure was refined using the SHELXL-97 program.
The R value is
20.8
for 3356 reflections
in the resolution range 10. to
1.4 Ångstroms
with Fobs > 0. sigma(Fobs).
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