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| Title: | | CRYSTAL STRUCTURE OF 9-AMINO-N-[2-(4-MORPHOLINYL)ETHYL]-4-ACRIDINECARBOXAMIDE BOUND TO D(CGTACG)2 | |
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| Molecular Description: | 5'-D(CpGpTpApCpG)-3'
9-AMINO-N-[2-(4-MORPHOLINYL)ETHYL]-4-ACRIDINECARBOXAMIDE |
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| Structural Features: | B DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chain | A: | | (DC) (DG) (DT) (DA) (DC) (DG) |
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| Primary Citation: | Adams, A., Guss, J.M., Denny, W.A., Wakelin, L.P.
Crystal structure of 9-amino-N-[2-(4-morpholinyl)ethyl]-4-acridinecarboxamide bound to d(CGTACG)2: implications for structure-activity relationships of acridinecarboxamide topoisomerase poisons.
Nucleic Acids Res.
, 30,
pp. 719 - 725, 2002.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
64
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| Cell Constants: |
| a = 30.239 | b = 30.239 | c = 39.340 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 120.00 | (degrees) |
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| Refinement: | The structure was refined using the SHELXL-97 program.
The R value is
21.5
for 1931 reflections
in the resolution range 40. to
1.8 Ångstroms
with I > 0.0 sigma(I).
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