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| Title: | | 2.4 ANGSTROM CRYSTAL STRUCTURE OF THE ASYMMETRIC PLATINUM COMPLEX {PT(AMMINE)(CYCLOHEXYLAMINE)}2+ BOUND TO A DODECAMER DNA DUPLEX | |
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| Molecular Description: | 5'-D(CpCpTpCpTpGpGpTpCpTpCpC)-3'
CIS-(AMMINE)(CYCLOHEXYLAMINE)DICHLOROPLATINUM(II) |
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| Structural Features: | B DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chains | A,C: | | (DC) (DC) (DT) (DC) (DT) (DG) (DG) (DT) (DC) (DT) (DC) (DC) |
| Chains | B,D: | | (DG) (DG) (DA) (DG) (DA) (DC) (DC) (DA) (DG) (DA) (DG) (DG) |
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| Primary Citation: | Silverman, A.P., Bu, W., Cohen, S.M., Lippard, S.J.
2.4-A Crystal Structure of the Asymmetric Platinum Complex {Pt(ammine)(cyclohexylamine)}2+ Bound to a Dodecamer DNA Duplex
J.Biol.Chem.
, 277,
pp. 49743 - 49749, 2002.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
1
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| Cell Constants: |
| a = 31.644 | b = 35.638 | c = 46.556 | (Ångstroms) |
 = 79.53 |  = 83.02 |  = 81.36 | (degrees) |
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| Refinement: | The structure was refined using the SHELXL-97 program.
The R value is
23.4
for reflections
in the resolution range 50.0 to
2.40 Ångstroms
with I > 2. sigma(I).
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