 | | | |
| Title: | | STRONG BINDING IN THE DNA MINOR GROOVE BY AN AROMATIC DIAMIDINE WITH A SHAPE THAT DOES NOT MATCH THE CURVATURE OF THE GROOVE | |
|
| Molecular Description: | 5'-D(CpGpCpGpApApTpTpCpGpCpG)-3'
carbonimidic dihydrazide derivative |
 |
| Structural Features: | B DOUBLE HELIX |
|
| Nucleic Acid Sequence: |
| | | |
| Chains | A,B: | | (DC) (DG) (DC) (DG) (DA) (DA) (DT) (DT) (DC) (DG) (DC) (DG) |
|
|
| Primary Citation: | Nguyen, B., Lee, M.P.H., Hamelberg, D., Joubert, A., Bailly, C., Brun, R., Neidle, S., Wilson, W.D.
Strong Binding in the DNA Minor Groove by an Aromatic Diamidine With a Shape That Does Not Match the Curvature of the Groove
J.Am.Chem.Soc.
, 124,
pp. 13680 - 13681, 2002.
|
|
| | | |
| Experimental Information: | X-RAY DIFFRACTION |
|
| Space Group: |
P
21
21
21
|
|
| Cell Constants: |
| a = 24.098 | b = 39.821 | c = 65.620 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
|
|
| Refinement: | The structure was refined using the SHELXL-97 program.
The R value is
20.2
for 5477 reflections
in the resolution range 10.00 to
1.78 Ångstroms
with I > 2. sigma(I).
|
|
|
