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| Title: | | THE CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN A DISACCHARIDE ANTHRACYCLINE AND THE DNA HEXAMER D(CGATCG) REVEALS TWO DIFFERENT BINDING SITES INVOLVING TWO DNA DUPLEXES | |
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| Molecular Description: | 5'-D(CpGpApTpCpG)-3' |
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| Structural Features: | B DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chains | A,B: | | (DC) (DG) (DA) (DT) (DC) (DG) |
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| Primary Citation: | Temperini, C., Messori, L., Orioli, P., Di Bugno, C., Animati, F., Ughetto, G.
The crystal structure of the complex between a disaccharide anthracycline and the DNA hexamer d(CGATCG) reveals two different binding sites involving two DNA duplexes
Nucleic Acids Res.
, 31,
pp. 1464 - 1469, 2003.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
43
21
2
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| Cell Constants: |
| a = 37.813 | b = 37.813 | c = 63.020 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the NUCLSQ program.
The R value is
22.4
for 2321 reflections
in the resolution range 8.0 to
2.15 Ångstroms
with Fobs > 2.0 sigma(Fobs).
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