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| Title: | | ROLE OF THE AMINO SUGAR IN DNA BINDING OF DISACCHARIDE ANTHRACYCLINES: CRYSTAL STRUCTURE OF MAR70/D(CGATCG) COMPLEX | |
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| Molecular Description: | 5'-D(CpGpApTpCpG)-3'
4'-EPI-4'-(2-DEOXYFUCOSE)DAUNOMYCIN |
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| Structural Features: | B DOUBLE HELIX |
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| Nucleic Acid Sequence: |
| | | |
| Chain | A: | | (DC) (DG) (DA) (DT) (DC) (DG) |
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| Primary Citation: | Temperini, C., Cirilli, M., Aschi, M., Ughetto, G.
Role of the amino sugar in DNA binding of disaccharide anthracyclines: crystal structure of the complex MAR70/d(CGATCG).
BIOORG.MED.CHEM.
, 13,
pp. 1673 - 1679, 2005.
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| Experimental Information: | X-RAY DIFFRACTION |
|
| Space Group: |
P
41
21
2
|
|
| Cell Constants: |
| a = 28.190 | b = 28.190 | c = 53.250 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the SHELXL-97 program.
The R value is
NaN
for reflections
in the resolution range 10.00 to
1.20 Ångstroms
with Fobs > 4.000 sigma(Fobs).
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