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| Title: | | CRYSTAL STRUCTURE OF THE MG2+-(CHROMOMYCIN A3)2-D(TTGGCCAA)2 COMPLEX REVEALS GGCC BINDING SPECIFICITY OF THE DRUG DIMER CHELATED BY METAL ION | |
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| Molecular Description: | 5'-D(TpTpGpGpCpCpApA)-3' |
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| Structural Features: | A DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chains | A,B,C,D: | | (DT) (DT) (DG) (DG) (DC) (DC) (DA) (DA) |
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| Primary Citation: | Hou, M.H., Robinson, H., Gao, Y.G., Wang, A.H.-J.
Crystal structure of the [Mg2+-(chromomycin A3)2]-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by a metal ion
Nucleic Acids Res.
, 32,
pp. 2214 - 2222, 2004.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
65
2
2
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| Cell Constants: |
| a = 42.23 | b = 42.23 | c = 246.11 | (Ångstroms) |
 = 90. |  = 90. |  = 120. | (degrees) |
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| Refinement: | The structure was refined using the CNS program.
The R value is
23.5
for 7815 reflections
in the resolution range 50. to
2.0 Ångstroms
with Fobs > 10. sigma(Fobs).
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