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| Title: | | THE STRUCTURE OF A THREE-WAY DNA JUNCTION IN COMPLEX WITH A METALLO-SUPRAMOLECULAR HELICATE REVEALS A NEW TARGET FOR DRUGS | |
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| Molecular Description: | 5'-D(CpGpTpApCpG)-3'
1,1-BIS(N-(4-PHENYL)-2-PYRIDYLCABOXALDIMINE)METHANE |
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| Structural Features: | RH TRIPLE HELIX, OPEN HELIX |
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| Nucleic Acid Sequence: |
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| Chains | A, B: | |
(DC) (DG) (DT) (DA) (DC) (DG)
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| Primary Citation: | Oleksi, A., Blanco, A.G., Boer, R., Uson, I., Aymami, J., Rodger, A., Hannon, M.J., Coll, M.
Molecular Recognition of a Three-Way DNA Junction by a Metallosupramolecular Helicate
ANGEW.CHEM.INT.ED.ENGL.
, 45,
pp. 1227 - 1231, 2006.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
41
3
2
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|
| Cell Constants: |
| a = 71.200 | b = 71.200 | c = 71.200 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Crystallization Conditions: |
| Method: | | VAPOR DIFFUSION, SITTING DROP |
| Drop: | | 0.08M Mg acetate, 0.05M TrisCl, PEG
EG400 |
| Reservoir: | | 0.08M Mg acetate, 0.05M TrisCl, PEG
EG400 |
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| Refinement: | The structure was refined using the SHELXL-97 program.
The R value is
25.6
for 6182 reflections
in the resolution range 22.5 to
1.7 Ångstroms
with I > 4 sigma(I).
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