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| Title: | | STRUCTURAL ADAPTATION AND CONSERVATION IN QUADRUPLEX-DRUG RECOGNITION | |
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| Molecular Description: | 5'-D(DTDApDGpDGpDGpDTpDTpDApDGpDGpDGpDTp
DTpDApDGpDGpDGpDTpDTpDApDGpDGpDG)-3' |
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| Structural Features: | QUADRUPLE HELIX, LOOP |
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| Nucleic Acid Sequence: |
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| Chains | A,B: | | (DT) (DA) (DG) (DG) (DG) (DT) (DT) (DA) (DG) (DG) (DG) (DT) (DT) (DA) (DG) (DG) (DG) (DT) (DT) (DA) (DG) (DG) (DG) |
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| Primary Citation: | Parkinson, G.N., Cuenca, F., Neidle, S.
Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes
J.Mol.Biol.
, 381,
pp. 1145 - 1156, 2008.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
1
21
1
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| Cell Constants: |
| a = 39.575 | b = 43.084 | c = 56.937 | (Ångstroms) |
 = 90.00 |  = 103.58 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the REFMAC 5.1.19 program.
The R value is
23.4
for 9497 reflections
in the resolution range 10.00 to
2.10 Ångstroms
with Fobs > 0. sigma(Fobs).
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