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| Title: | | A BIMOLECULAR PARALLEL-STRANDED HUMAN TELOMERIC QUADRUPLEX IN COMPLEX WITH A 3,6,9-TRISUBSTITUTED ACRIDINE MOLECULE BRACO19 | |
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| Molecular Description: | 5'-D(DTpDApDGpDGpDGpDTpDTpDApDGpDGpDGp
DT)-3' |
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| Structural Features: | QUADRUPLE HELIX, bulges, OVERHANGING BASES |
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| Nucleic Acid Sequence: |
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| Chains | A,B: | | (DT) (DA) (DG) (DG) (DG) (DT) (DT) (DA) (DG) (DG) (DG) (DT) |
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| Primary Citation: | Campbell, N.H., Parkinson, G.N., Reszka, A.P., Neidle, S.
Structural basis of DNA quadruplex recognition by an acridine drug.
J.Am.Chem.Soc.
, 130,
pp. 6722 - 6724, 2008.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
I
4
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| Cell Constants: |
| a = 70.338 | b = 70.338 | c = 34.293 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the REFMAC 5.2.0019 program.
The R value is
18.3
for 2852 reflections
in the resolution range 35.17 to
2.50 Ångstroms
. |
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