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| Title: | | STRUCTURAL COMPARISON OF ANTICANCER DRUG-DNA COMPLEXES. ADRIAMYCIN AND DAUNOMYCIN | |
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| Molecular Description: | 5'-D(CpGpApTpCpG)-3'
DAUNOMYCIN |
 |
| Structural Features: | RH DOUBLE HELIX |
|
| Nucleic Acid Sequence: |
| | | |
| Chain | A: | | (DC) (DG) (DA) (DT) (DC) (DG) |
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| Primary Citation: | Frederick, C.A., Williams, L.D., Ughetto, G., van der Marel, G.A., van Boom, J.H., Rich, A., Wang, A.H.
Structural comparison of anticancer drug-DNA complexes: adriamycin and daunomycin.
Biochemistry
, 29,
pp. 2538 - 2549, 1990.
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| | | |
| Experimental Information: | X-RAY DIFFRACTION |
|
| Space Group: |
P
41
21
2
|
|
| Cell Constants: |
| a = 28.110 | b = 28.110 | c = 53.080 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
|
|
| Refinement: | The structure was refined using the NUCLSQ program.
The R value is
17.5
for 2731 reflections
in the resolution range 10.000 to
1.500 Ångstroms
with Fobs > 2.000 sigma(Fobs).
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