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| Title: | | FACILE FORMATION OF A CROSSLINKED ADDUCT BETWEEN DNA AND THE DAUNORUBICIN DERIVATIVE MAR70 MEDIATED BY FORMALDEHYDE: MOLECULAR STRUCTURE OF THE MAR70-D(CGTNACG) COVALENT ADDUC | |
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| Molecular Description: | 5'-D(CpGpTpApCpG)-3'
MAR70 |
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| Structural Features: | RH DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chain | A: | | (DC) (DG) (DT) (DA) (DC) (DG) |
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| Primary Citation: | Gao, Y.G., Liaw, Y.C., Li, Y.K., van der Marel, G.A., van Boom, J.H., Wang, A.H.
Facile formation of a crosslinked adduct between DNA and the daunorubicin derivative MAR70 mediated by formaldehyde: molecular structure of the MAR70-d(CGTnACG) covalent adduct.
Proc.Natl.Acad.Sci.USA
, 88,
pp. 4845 - 4849, 1991.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
41
21
2
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| Cell Constants: |
| a = 28.010 | b = 28.010 | c = 53.110 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the NUCLSQ program.
The R value is
16.4
for 2168 reflections
in the resolution of 1.500
with Fobs > 2.000 sigma(Fobs).
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