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| Title: | | ANTHRACYCLINE-DNA INTERACTIONS AT UNFAVOURABLE BASE BASE-PAIR TRIPLET-BINDING SITES: STRUCTURES OF D(CGGCCG)/DAUNOMYCIN AND D(TGGCCA)/ADRIAMYCIN COMPL | |
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| Molecular Description: | 5'-D(CpGpGpCpCpG)-3'
DAUNOMYCIN |
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| Structural Features: | RH DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chain | A: | | (DC) (DG) (DG) (DC) (DC) (DG) |
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| Primary Citation: | Leonard, G.A., Hambley, T.W., McAuley-Hecht, K., Brown, T., Hunter, W.N.
Anthracycline-DNA interactions at unfavourable base-pair triplet-binding sites: structures of d(CGGCCG)/daunomycin and d(TGGCCA)/adriamycin complexes.
Acta Crystallogr.,Sect.D
, 49,
pp. 458 - 467, 1993.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
41
21
2
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| Cell Constants: |
| a = 28.070 | b = 28.070 | c = 53.350 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the NUCLSQ program.
The R value is
20.8
for 1108 reflections
in the resolution range 7.000 to
1.900 Ångstroms
with Fobs > 2.000 sigma(Fobs).
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