 | | | |
| Title: | | ANTHRACYCLINE-DNA INTERACTIONS AT UNFAVOURABLE BASE BASE-PAIR TRIPLET-BINDING SITES: STRUCTURES OF D(CGGCCG)/DAUNOMYCIN AND D(TGGCCA)/ADRIAMYCIN COMPL | |
|
| Molecular Description: | 5'-D(TpGpGpCpCpA)-3'
ADRIAMYCIN |
 |
| Structural Features: | RH DOUBLE HELIX |
|
| Nucleic Acid Sequence: |
| | | |
| Chain | A: | | (DT) (DG) (DG) (DC) (DC) (DA) |
|
|
| Primary Citation: | Leonard, G.A., Hambley, T.W., McAuley-Hecht, K., Brown, T., Hunter, W.N.
Anthracycline-DNA interactions at unfavourable base-pair triplet-binding sites: structures of d(CGGCCG)/daunomycin and d(TGGCCA)/adriamycin complexes.
Acta Crystallogr.,Sect.D
, 49,
pp. 458 - 467, 1993.
|
|
| | | |
| Experimental Information: | X-RAY DIFFRACTION |
|
| Space Group: |
P
41
21
2
|
|
| Cell Constants: |
| a = 28.010 | b = 28.010 | c = 52.990 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
|
|
| Refinement: | The structure was refined using the NUCLSQ program.
The R value is
21.6
for 1475 reflections
in the resolution range 7.000 to
1.700 Ångstroms
with Fobs > 2.000 sigma(Fobs).
|
|
|
