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| Title: | | INTERACTIONS BETWEEN MORPHOLINYL ANTHRACYCLINES AND DNA: THE CRYSTAL STRUCTURE OF A MORPHOLINO DOXORUBICIN BOUND TO D(CGTACG) | |
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| Molecular Description: | 5'-D(CpGpTpApCpG)-3'
3'-DESAMINO-3'-(2-METHOXY-4-MORPHOLINYL)-DOXORUBICIN |
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| Structural Features: | RH DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chains | A,B: | | (DC) (DG) (DT) (DA) (DC) (DG) |
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| Primary Citation: | Cirilli, M., Bachechi, F., Ughetto, G., Colonna, F.P., Capobianco, M.L.
Interactions between morpholinyl anthracyclines and DNA. The crystal structure of a morpholino doxorubicin bound to d(CGTACG).
J.Mol.Biol.
, 230,
pp. 878 - 889, 1993.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
1
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| Cell Constants: |
| a = 18.010 | b = 18.830 | c = 26.750 | (Ångstroms) |
 = 92.60 |  = 100.50 |  = 94.90 | (degrees) |
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| Refinement: | The structure was refined using the NUCLSQ program.
The R value is
19.2
for 3588 reflections
in the resolution range 10.000 to
1.500 Ångstroms
with Fobs > 2.000 sigma(Fobs).
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