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| Title: | | MOLECULAR STRUCTURE OF THE HALOGENATED ANTI-CANCER DRUG IODODOXORUBICIN COMPLEXED WITH D(TGTACA) AND D(CGATCG) | |
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| Molecular Description: | 5'-D(CpGpApTpCpG)-3'
4'-DEOXY-4'-IODODOXORUBICIN |
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| Structural Features: | RH DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chain | A: | | (DC) (DG) (DA) (DT) (DC) (DG) |
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| Primary Citation: | Berger, I., Su, L., Spitzner, J.R., Kang, C., Burke, T.G., Rich, A.
Molecular structure of the halogenated anti-cancer drug iododoxorubicin complexed with d(TGTACA) and d(CGATCG).
Nucleic Acids Res.
, 23,
pp. 4488 - 4494, 1995.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
41
21
2
|
|
| Cell Constants: |
| a = 27.730 | b = 27.730 | c = 52.490 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the X-PLOR program.
The R value is
18.0
for 3028 reflections
in the resolution range 10.000 to
1.500 Ångstroms
with Fobs > 2.000 sigma(Fobs).
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