NDB ID: DDF068
Title: SUBSTITUTIONS AT C2' OF DAUNOSAMINE IN THE ANTICANCER DAUNORUBICIN ALTER ITS DNA-BINDING SEQUENCE SPECIFICITY Molecular Description: 5'-D(CpGp(G49)pCpCpG)-3' 2'-BROMO-4'-EPIDAUNORUBICIN Structural Features: RH DOUBLE HELIX Nucleic Acid Sequence: Chain A: (DC) (DG) (G49) (DC) (DC) (DG) Primary Citation: Gao, Y.G., Priebe, W., Wang, A.H. Substitutions at C2' of daunosamine in the anticancer drug daunorubicin alter its DNA-binding sequence specificity. Eur.J.Biochem. , 240, pp. 331 - 335, 1996. Experimental Information: X-RAY DIFFRACTION Space Group: P  41   21   2 Cell Constants: a = 28.250 b = 28.250 c = 53.670 (Ångstroms) = 90.00 = 90.00 = 90.00 (degrees) Refinement: The structure was refined using the NUCLSQ program. The R value is 18.3 for 1860 reflections in the resolution range 10.000 to 1.800 Ångstroms with Fobs > 4.000 sigma(Fobs).	Biological Assembly 1 Other Views Asymmetric Unit Crystal Packing Enlarge Biological Assembly 1
Coordinate + Structure Data Asymmetric Unit coordinates (pdb format, Unix compressed(.gz)) Asymmetric Unit coordinates (cif format, Unix compressed(.gz)) Biological Assembly coordinates (pdb format) XML | Complete with coordinates (xml format, GNU compressed(.gz)) XML | Coordinates only (xml format, GNU compressed(.gz)) XML | Header only (xml format, GNU compressed(.gz))	Derivative Data Nucleic Acid Backbone Torsions Base Pair Parameters Base Pair Step Parameters Hydrogen Bonding Classification
Links
The RCSB Protein Data Bank: 278D
PubMed: 8841395
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