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| Title: | | 1.3 A STRUCTURE DETERMINATION OF THE D(CG(5-BRU)ACG)2/6-BROMO-9-AMINO-DACA COMPLEX | |
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| Molecular Description: | 5'-D(CpGp(BRU)pApCpG)-3'
ACRIDINE-4-CARBOXAMIDE DERIVATIVE |
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| Structural Features: | RH DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chain | A: | | (DC) (DG) (BRU) (DA) (DC) (DG) |
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| Primary Citation: | Todd, A.K., Adams, A., Thorpe, J.H., Denny, W.A., Wakelin, L.P., Cardin, C.J.
Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution.
J.Med.Chem.
, 42,
pp. 536 - 540, 1999.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
64
|
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| Cell Constants: |
| a = 30.110 | b = 30.110 | c = 39.560 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 120.00 | (degrees) |
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| Refinement: | The structure was refined using the SHELXL-96 program.
The R value is
18.5
for reflections
in the resolution range 8.0 to
1.30 Ångstroms
. |
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