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| Title: | | BINDING OF THE MODIFIED DAUNORUBICIN WP401 ADJACENT TO A T-G BASE PAIR INDUCES THE REVERSE WATSON-CRICK CONFORMATION: CRYSTAL STRUCTURES OF THE WP401-TGGCCG AND WP401-CGG[BR5C]CG COMPLEXES | |
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| Molecular Description: | 5'-D(TpGp(G49)pCpCpG)-3'
2'-BROMO-4'-EPIDAUNORUBICIN |
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| Structural Features: | RH DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chain | A: | | (DT) (DG) (DG) (DC) (DC) (DG) |
| Chain | B: | | (DT) (DG) (G49) (DC) (DC) (DG) |
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| Primary Citation: | Dutta, R., Gao, Y.G., Priebe, W., Wang, A.H.
Binding of the modified daunorubicin WP401 adjacent to a T-G base pair induces the reverse Watson-Crick conformation: crystal structures of the WP401-TGGCCG and WP401-CGG[br5C]CG complexes.
Nucleic Acids Res.
, 26,
pp. 3001 - 3005, 1998.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
43
2
2
|
|
| Cell Constants: |
| a = 37.200 | b = 37.200 | c = 70.530 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
|
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| Refinement: | The structure was refined using the X-PLOR program.
The R value is
24.5
for 2781 reflections
in the resolution range 10.000 to
2.100 Ångstroms
with Fobs > 2.000 sigma(Fobs).
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