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| Title: | | MULTIPLE BINDING MODES OF ANTICANCER DRUG ACTINOMYCIN D: X-RAY, MOLECULAR MODELING, AND SPECTROSCOPIC STUDIES OF D(GAAGCTTC)2-ACTINOMYCIN D COMPLEXES AND ITS HOST DNA | |
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| Molecular Description: | ACTINOMYCIN D/DNA Complex |
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| Structural Features: | RH DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chains | A,B: | | (DG) (DA) (DA) (DG) (DC) (DT) (DT) (DC) |
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| Protein Sequence: |
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| Primary Citation: | Kamitori, S., Takusagawa, F.
Multiple Binding Modes of Anticancer Drug Actinomycin D: X-Ray, Molecular Modeling, and Spectroscopic Studies of D(Gaagcttc)2-Actinomycin D Complexes and its Host DNA
J.Am.Chem.Soc.
, 116,
pp. 4154, 1994.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
F
2
2
2
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| Cell Constants: |
| a = 69.900 | b = 61.410 | c = 54.250 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the X-PLOR program.
The R value is
20.2
for 1016 reflections
in the resolution range 8.00 to
3.00 Ångstroms
with Fobs > 2.000 sigma(Fobs).
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