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| Title: | | SELECTIVITY OF F8-ACTINOMYCIN D FOR RNA:DNA HYBRIDS AND ITS ANTI-LEUKEMIA ACTIVITY | |
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| Molecular Description: | 5'-D(GpApApGpCpTpTpC)-3'
F8-ACTINOMYCIN D |
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| Structural Features: | RH DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chains | A,B: | | (DG) (DA) (DA) (DG) (DC) (DT) (DT) (DC) |
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| Primary Citation: | Takusagawa, F., Takusagawa, K.T., Carlson, R.G., Weaver, R.F.
Selectivity of F8-actinomycin D for RNA:DNA hybrids and its anti-leukemia activity.
Bioorg.Med.Chem.
, 5,
pp. 1197 - 1207, 1997.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
31
2
1
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| Cell Constants: |
| a = 62.770 | b = 62.770 | c = 43.030 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 120.00 | (degrees) |
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| Refinement: | The structure was refined using the X-PLOR program.
The R value is
21.2
for 1839 reflections
in the resolution range 7.000 to
3.000 Ångstroms
with Fobs > 0.000 sigma(Fobs).
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