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| Title: | | CRYSTAL STRUCTURE OF A DOUBLE-STRANDED DNA DECAMER CONTAINING A CISPLATIN INTERSTRAND CROSS-LINK ADDUCT | |
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| Molecular Description: | 5'-D(CpCpTpCpGpCpTpCpTpC)-3'
5'-D(GpApGpApGpCpGpApGpG)-3'
CIS-PLATINUM |
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| Structural Features: | RH DOUBLE HELIX, FLIPPED-OUT BASES, INTERSTRAND CROSS-LINK |
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| Nucleic Acid Sequence: |
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| Chain | A: | | (DC) (DC) (DT) (DC) (DG) (DC) (DT) (DC) (DT) (DC) |
| Chain | B: | | (DG) (DA) (DG) (DA) (DG) (DC) (DG) (DA) (DG) (DG) |
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| Primary Citation: | Coste, F., Malinge, J.M., Serre, L., Shepard, W., Roth, M., Leng, M., Zelwer, C.
Crystal structure of a double-stranded DNA containing a cisplatin interstrand cross-link at 1.63 A resolution: hydration at the platinated site.
Nucleic Acids Res.
, 27,
pp. 1837 - 1846, 1999.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
C
1
2
1
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| Cell Constants: |
| a = 42.890 | b = 29.980 | c = 46.570 | (Ångstroms) |
 = 90.00 |  = 95.98 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the SHELXL-96 program.
The R value is
16.9
for 6983 reflections
in the resolution range 20.0 to
1.63 Ångstroms
with Fobs > 0.0 sigma(Fobs).
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