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| Title: | | CRYSTAL STRUCTURE OF A DOUBLE-STRANDED DNA CONTAINING THE MAJOR ADDUCT OF THE ANTICANCER DRUG CISPLATIN | |
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| Molecular Description: | 5'-D(CpCp(BRU)pCpTp[PT(NH3)2(GpGP)]TpCp
TpCpC)-3' |
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| Structural Features: | RH DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chains | A,C: | | (DC) (DC) (BRU) (DC) (DT) (DG) (DG) (DT) (DC) (DT) (DC) (DC) |
| Chains | B,D: | | (DG) (DG) (DA) (DG) (DA) (DC) (DC) (DA) (DG) (DA) (DG) (DG) |
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| Primary Citation: | Takahara, P.M., Rosenzweig, A.C., Frederick, C.A., Lippard, S.J.
Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin.
Nature
, 377,
pp. 649 - 652, 1995.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
1
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| Cell Constants: |
| a = 31.270 | b = 35.460 | c = 47.010 | (Ångstroms) |
 = 79.81 |  = 84.75 |  = 82.79 | (degrees) |
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| Refinement: | The structure was refined using the X-PLOR 3.1 program.
The R value is
20.6
for 5797 reflections
in the resolution range 8.000 to
2.600 Ångstroms
with Fobs > 1.000 sigma(Fobs).
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