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| Title: | | CRYSTAL STRUCTURE OF A COVALENT DNA-DRUG ADDUCT: ANTHRAMYCIN BOUND TO C-C-A-A-C-G-T-T-G-G, AND A MOLECULAR EXPLANATION OF SPECIFICITY | |
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| Molecular Description: | 5'-D(CpCpApApCpGpTpTpGpG)-3'
ANTHRAMYCIN |
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| Structural Features: | B DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chain | A: | | (DC) (DC) (DA) (DA) (DC) (DG) (DT) (DT) (DG) (DG) |
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| Primary Citation: | Kopka, M.L., Goodsell, D.S., Baikalov, I., Grzeskowiak, K., Cascio, D., Dickerson, R.E.
Crystal structure of a covalent DNA-drug adduct: anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity.
Biochemistry
, 33,
pp. 13593 - 13610, 1994.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
32
2
1
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| Cell Constants: |
| a = 23.950 | b = 23.950 | c = 88.890 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 120.00 | (degrees) |
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| Refinement: | The structure was refined using the NUCLSQ program.
The R value is
21.2
for 1212 reflections
in the resolution range 8.000 to
2.300 Ångstroms
with Fobs > 2.000 sigma(Fobs).
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