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| Title: | | MOLECULAR STRUCTURE OF THE A-TRACT DNA DODECAMER D(CGCAAATTTGCG) COMPLEXED WITH THE MINOR GROOVE BINDING DRUG NETROPSIN | |
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| Molecular Description: | 5'-D(CpGpCpApApApTpTpTpGpCpG)-3'
NETROPSIN |
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| Structural Features: | B DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chains | A,B: | | (DC) (DG) (DC) (DA) (DA) (DA) (DT) (DT) (DT) (DG) (DC) (DG) |
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| Primary Citation: | Tabernero, L., Verdaguer, N., Coll, M., Fita, I., van der Marel, G.A., van Boom, J.H., Rich, A., Aymami, J.
Molecular structure of the A-tract DNA dodecamer d(CGCAAATTTGCG) complexed with the minor groove binding drug netropsin.
Biochemistry
, 32,
pp. 8403 - 8410, 1993.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
21
21
21
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| Cell Constants: |
| a = 25.650 | b = 42.030 | c = 65.330 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the X-PLOR program.
The R value is
19.8
for 2348 reflections
in the resolution range 8.000 to
2.200 Ångstroms
with Fobs > 2.000 sigma(Fobs).
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