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| Title: | | THREE-DIMENSIONAL CRYSTAL STRUCTURE OF THE A-TRACT DNA DODECAMER D(CGCAAATTTGCG) COMPLEXED WITH THE MINOR-GROOVE-BINDING DRUG HOECHST 33258 | |
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| Molecular Description: | 5'-D(CpGpCpApApApTpTpTpGpCpG)-3'
HOECHST 33258 |
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| Structural Features: | B DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chains | A,B: | | (DC) (DG) (DC) (DA) (DA) (DA) (DT) (DT) (DT) (DG) (DC) (DG) |
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| Primary Citation: | Vega, M.C., Garcia Saez, I., Aymami, J., Eritja, R., Van der Marel, G.A., Van Boom, J.H., Rich, A., Coll, M.
Three-dimensional crystal structure of the A-tract DNA dodecamer d(CGCAAATTTGCG) complexed with the minor-groove-binding drug Hoechst 33258.
Eur.J.Biochem.
, 222,
pp. 721 - 726, 1994.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
21
21
21
|
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| Cell Constants: |
| a = 25.500 | b = 41.400 | c = 65.300 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the X-PLOR program.
The R value is
20.0
for 2253 reflections
in the resolution range 10.000 to
2.440 Ångstroms
with Fobs > 2.000 sigma(Fobs).
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