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| Title: | | SEQUENCE-DEPENDENT EFFECTS IN DRUG-DNA INTERACTION: THE CRYSTAL STRUCTURE OF HOECHST 33258 BOUND TO THE D(CGCAAATTTGCG)2 DUPLEX | |
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| Molecular Description: | 5'-D(CpGpCpApApApTpTpTpGpCpG)-3'
HOECHST 33258 |
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| Structural Features: | B DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chains | A,B: | | (DC) (DG) (DC) (DA) (DA) (DA) (DT) (DT) (DT) (DG) (DC) (DG) |
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| Primary Citation: | Spink, N., Brown, D.G., Skelly, J.V., Neidle, S.
Sequence-dependent effects in drug-DNA interaction: the crystal structure of Hoechst 33258 bound to the d(CGCAAATTTGCG)2 duplex.
Nucleic Acids Res.
, 22,
pp. 1607 - 1612, 1994.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
21
21
21
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| Cell Constants: |
| a = 25.270 | b = 41.320 | c = 65.110 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the NUCLSQ program.
The R value is
18.5
for 2125 reflections
in the resolution range 8.000 to
2.250 Ångstroms
with I > 2.000 sigma(I).
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