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| Title: | | ISOHELICITY AND PHASING IN DRUG-DNA SEQUENCE RECOGNITION: CRYSTAL STRUCTURE OF A TRIS(BENZIMIDAZOLE)-OLIGONUCLEOTIDE COMPLEX | |
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| Molecular Description: | 5'-D(CpGpCpApApApTpTpTpGpCpG)-3'
TRIBIZ |
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| Structural Features: | B DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chains | A,B: | | (DC) (DG) (DC) (DA) (DA) (DA) (DT) (DT) (DT) (DG) (DC) (DG) |
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| Primary Citation: | Clark, G.R., Gray, E.J., Neidle, S., Li, Y.H., Leupin, W.
Isohelicity and phasing in drug--DNA sequence recognition: crystal structure of a tris(benzimidazole)--oligonucleotide complex.
Biochemistry
, 35,
pp. 13745 - 13752, 1996.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
21
21
21
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| Cell Constants: |
| a = 24.700 | b = 40.820 | c = 64.900 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the X-PLOR program.
The R value is
17.4
for 2534 reflections
in the resolution range 8.000 to
2.200 Ångstroms
with Fobs > 2.000 sigma(Fobs).
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