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| Title: | | STRUCTURE OF 2,5-BIS{[4-(N-ETHYLAMIDINO)PHENYL]}FURAN COMPLEXED TO 5'-D(CPGPCPGPAPAPTPTPCPGPCPG)-3'. A MINOR GROOVE DRUG COMPLEX, SHOWING PATTERNS OF GROOVE HYDRATION | |
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| Molecular Description: | 5'-D(CpGpCpGpApApTpTpCpGpCpG)-3'
2,5-BIS{[4-(N-ETHYLAMIDINO)] PHENYL}FURAN |
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| Structural Features: | B DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Chains | A,B: | | (DC) (DG) (DC) (DG) (DA) (DA) (DT) (DT) (DC) (DG) (DC) (DG) |
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| Primary Citation: | Guerri, A., Simpson, I.J., Neidle, S.
Visualisation of extensive water ribbons and networks in a DNA minor-groove drug complex.
Nucleic Acids Res.
, 26,
pp. 2873 - 2878, 1998.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
21
21
21
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| Cell Constants: |
| a = 24.240 | b = 39.940 | c = 65.880 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the SHELXL-97 program.
The R value is
17.0
for 5386 reflections
in the resolution range 7.000 to
1.850 Ångstroms
with Fobs > 4.000 sigma(Fobs).
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