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| Title: | | STRUCTURE OF A CATALYTIC COMPLEX OF HIV-1 REVERSE TRANSCRIPTASE: IMPLICATIONS FOR NUCLEOSIDE ANALOG DRUG RESISTANCE | |
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| Molecular Description: |
REVERSE TRANSCRIPTASE (E.C.2.7.7.49) MUTANT (P1K
Q258C
E478Q)/DNA COMPLEX |
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| Structural Features: | B DOUBLE HELIX, FLIPPED-OUT BASES, OVERHANGING BASES |
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| Nucleic Acid Sequence: |
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| Protein Sequence: |
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| Primary Citation: | Huang, H., Chopra, R., Verdine, G.L., Harrison, S.C.
Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance.
Science
, 282,
pp. 1669 - 1675, 1998.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
21
21
21
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| Cell Constants: |
| a = 78.840 | b = 150.700 | c = 280.880 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the X-PLOR 3.851 program.
The R value is
22.4
for 49983 reflections
in the resolution range 12.0 to
3.2 Ångstroms
with Fobs > 2.0 sigma(Fobs).
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