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| Title: | | HUMAN APE1 ENDONUCLEASE WITH BOUND ABASIC DNA AND MN2+ ION | |
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| Molecular Description: |
MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE (E.C.4.2.99.18)/DNA COMPLEX |
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| Structural Features: | B DOUBLE HELIX, FLIPPED-OUT BASES, OVERHANGING BASES |
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| Nucleic Acid Sequence: |
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| Chains | X,U: | | (DC) (DT) (DA) (DC) |
| Chains | Y,V: | | (3DR) (DG) (DA) (DT) (DC) |
| Chains | Z,W: | | (DG) (DA) (DT) (DC) (DG) (DG) (DT) (DA) (DG) |
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| Protein Sequence: |
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| Primary Citation: | Mol, C.D., Izumi, T., Mitra, S., Tainer, J.A.
DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination
Nature
, 403,
pp. 451 - 456, 2000.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
21
21
21
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| Cell Constants: |
| a = 90.06 | b = 98.35 | c = 101.05 | (Ångstroms) |
 = 90.0 |  = 90.0 |  = 90.0 | (degrees) |
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| Refinement: | The structure was refined using the X-PLOR 3.851 program.
The R value is
18.3
for 12390 reflections
in the resolution range 20.0 to
3.0 Ångstroms
with Fobs > 3.0 sigma(Fobs).
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