NDB ID: PD0125
Title: CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX Molecular Description: DNA TOPOISOMERASE I (E.C.5.99.1.2)/DNA COMPLEX Structural Features: B DOUBLE HELIX Nucleic Acid Sequence: Chain C: Click here for sequence. Chain D: Click here for sequence. Protein Sequence: Chain A: Click here for sequence. Primary Citation: Redinbo, M.R., Champoux, J.J., Hol, W.G. Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA. Biochemistry , 39, pp. 6832 - 6840, 2000. Experimental Information: X-RAY DIFFRACTION Space Group: P  1  21   1 Cell Constants: a = 56.98 b = 124.92 c = 72.29 (Ångstroms) = 90.0 = 93.84 = 90.0 (degrees) Refinement: The structure was refined using the X-PLOR 3.1 program. The R value is 21.4 for 29616 reflections in the resolution range 15. to 2.6 Ångstroms with I > 1. sigma(I).	Biological Assembly 1 Other Views Asymmetric Unit Enlarge Biological Assembly 1
Coordinate + Structure Data Asymmetric Unit coordinates (pdb format, Unix compressed(.gz)) Asymmetric Unit coordinates (cif format, Unix compressed(.gz)) Biological Assembly coordinates (pdb format) XML | Complete with coordinates (xml format, GNU compressed(.gz)) XML | Coordinates only (xml format, GNU compressed(.gz)) XML | Header only (xml format, GNU compressed(.gz))	Derivative Data Nucleic Acid Backbone Torsions Base Pair Parameters Base Pair Step Parameters Hydrogen Bonding Classification
Links
The RCSB Protein Data Bank: 1EJ9
PubMed: 10841763
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