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| Title: | | CRYSTAL STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE BOUND TO UNCLEAVED SUBSTRATE-CONTAINING DNA | |
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| Molecular Description: |
URACIL-DNA GLYCOSYLASE (E.C.3.2.2.3)/DNA COMPLEX |
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| Structural Features: | B DOUBLE HELIX, FLIPPED-OUT BASES, OVERHANGING BASES |
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| Nucleic Acid Sequence: |
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| Chain | B: | | (DT) (DG) (DT) (P2U) (DA) (DT) (DC) (DT) (DT) |
| Chain | C: | | (DA) (DA) (DA) (DG) (DA) (DT) (DA) (DA) (DC) (DA) |
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| Protein Sequence: |
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| Primary Citation: | Parikh, S.S., Walcher, G., Jones, G.D., Slupphaug, G., Krokan, H.E., Blackburn, G.M., Tainer, J.A.
Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.
Proc.Natl.Acad.Sci.USA
, 97,
pp. 5083 - 5088, 2000.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
21
21
21
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| Cell Constants: |
| a = 48.655 | b = 64.815 | c = 94.964 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the CNS program.
The R value is
21.6
for 26133 reflections
in the resolution range 20.0 to
1.8 Ångstroms
with I > 1.0 sigma(I).
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