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| Title: | | HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE POISON TOPOTECAN AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX | |
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| Molecular Description: |
DNA TOPOISOMERASE I (E.C.5.99.1.2)/DNA Complex |
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| Structural Features: | B DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Protein Sequence: |
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| Primary Citation: | Staker, B.L., Hjerrild, K., Feese, M.D., Behnke, C.A., Burgin Jr., A.B., Stewart, L.J.
The mechanism of topoisomerase I poisoning by a camptothecin analog
Proc.Natl.Acad.Sci.USA
, 99,
pp. 15387 - 15392, 2002.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
1
21
1
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| Cell Constants: |
| a = 57.093 | b = 116.260 | c = 75.217 | (Ångstroms) |
 = 90.00 |  = 94.16 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the CNX 2000.1 program.
The R value is
22.9
for 45727 reflections
in the resolution range 19.89 to
2.10 Ångstroms
with Fobs > 0. sigma(Fobs).
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