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| Title: | | HUMAN DNA TOPOISOMERASE I (70 KDA) IN NON-COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX CONTAINING AN 8-OXOG LESION | |
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| Molecular Description: |
DNA topoisomerase I (E.C.5.99.1.2)/DNA Complex |
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| Structural Features: | B DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Protein Sequence: |
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| Primary Citation: | Lesher, D.T., Pommier, Y., Stewart, L., Redinbo, M.R.
8-Oxoguanine rearranges the active site of human topoisomerase I
Proc.Natl.Acad.Sci.USA
, 99,
pp. 12102 - 12107, 2002.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
1
21
1
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| Cell Constants: |
| a = 57.200 | b = 122.500 | c = 72.000 | (Ångstroms) |
 = 90.00 |  = 97.40 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the CNS 1.0 program.
The R value is
25.6
for 16401 reflections
in the resolution range 19.87 to
3.14 Ångstroms
with Fobs > 0.0 sigma(Fobs).
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