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| Title: | | CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE-PRIMER | |
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| Structural Features: | B DOUBLE HELIX |
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| Nucleic Acid Sequence: |
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| Protein Sequence: |
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| Primary Citation: | Sarafianos, S.G., Das, K., Clark Jr., A.D., Ding, J., Boyer, P.L., Hughes, S.H., Arnold, E.
Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids.
Proc.Natl.Acad.Sci.USA
, 96,
pp. 10027 - 10032, 1999.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
32
1
2
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| Cell Constants: |
| a = 169.180 | b = 169.180 | c = 221.910 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 120.00 | (degrees) |
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| Refinement: | The structure was refined using the X-PLOR 3.843 program.
The R value is
26.2
for 39033 reflections
in the resolution range 10. to
3.5 Ångstroms
with I > 1. sigma(I).
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