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| Title: | | HUMAN TOPOISOMERASE I ARA-C COMPLEX | |
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| Molecular Description: | DNA topoisomerase I/DNA Complex |
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| Nucleic Acid Sequence: |
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| Chain | B: | | (DA) (DA) (DA) (DA) (DA) (DG) (DA) (DC) (DU) (UBB) |
| Chain | C: | | (GNG) (DG) (DA) (DA) (DA) (DA) (DA) (DU) (DU) (DU) (DU) (DT) |
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| Protein Sequence: |
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| Primary Citation: | Chrencik, J.E., Burgin, A.B., Pommier, Y., Stewart, L., Redinbo, M.R.
Structural Impact of the Leukemia Drug 1-beta-D-Arabinofuranosylcytosine (Ara-C) on the Covalent Human Topoisomerase I-DNA Complex
J.Biol.Chem.
, 278,
pp. 12461 - 12466, 2003.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
32
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| Cell Constants: |
| a = 72.97 | b = 72.97 | c = 186.29 | (Ångstroms) |
 = 90. |  = 90. |  = 120. | (degrees) |
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| Refinement: | The structure was refined using the CNS program.
The R value is
23.5
for 13878 reflections
in the resolution range 44.29 to
3.10 Ångstroms
with Fobs > 0.0 sigma(Fobs).
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