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| Title: | | CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE (TDP1) IN COMPLEX WITH VANADATE, DNA AND A HUMAN TOPOISOMERASE I-DERIVED PEPTIDE | |
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| Molecular Description: |
tyrosyl-DNA phosphodiesterase 1/DNA Complex |
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| Structural Features: | SINGLE STRAND |
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| Nucleic Acid Sequence: |
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| Chains | D,F: | | (DA) (DG) (DA) (DG) (DT) (DT) |
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| Protein Sequence: |
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| Primary Citation: | Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.J.
Crystal structure of a transition state mimic for Tdp1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide
Chem.Biol.
, 10,
pp. 139 - 147, 2003.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
21
21
21
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| Cell Constants: |
| a = 49.803 | b = 104.719 | c = 193.924 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the REFMAC 5.1.24 program.
The R value is
20.6
for 41018 reflections
in the resolution range 95.35 to
2.30 Ångstroms
with Fobs > 0. sigma(Fobs).
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