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| Title: | | CRYSTAL STRUCTURE OF UP1 COMPLEXED WITH D(TAGG(6MI)TTAGGG): A HUMAN TELOMERIC REPEAT CONTAINING 6-METHYL-8-(2-DEOXY-BETA-RIBOFURANOSYL)ISOXANTHOPTERIDINE (6MI) | |
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| Molecular Description: |
Heterogeneous nuclear ribonucleoprotein A1/DNA Complex |
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| Structural Features: | SINGLE STRAND, LOOP, FLIPPED-OUT BASES, NICKED |
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| Nucleic Acid Sequence: |
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| Chain | B: | | (DT) (DA) (DG) (DG) (6MI) (DT) (DT) (DA) (DG) (DG) (DG) |
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| Protein Sequence: |
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| Primary Citation: | Myers, J.C., Moore, S.A., Shamoo, Y.
Structure-based incorporation of 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine into the human telomeric repeat DNA as a probe for UP1 binding and destabilization of G-tetrad structures
J.BIOL.CHEM.
, 278,
pp. 42300 - 42306, 2003.
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| Experimental Information: | X-RAY DIFFRACTION |
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| Space Group: |
P
43
21
2
|
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| Cell Constants: |
| a = 51.807 | b = 51.807 | c = 172.330 | (Ångstroms) |
 = 90.00 |  = 90.00 |  = 90.00 | (degrees) |
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| Refinement: | The structure was refined using the CNS 1.0 program.
The R value is
23.4
for 13930 reflections
in the resolution range 19.89 to
2.10 Ångstroms
with I > 0.0 sigma(I).
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